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Chemical Name: Acriflavine hydrochloride
CAS No: 8063-24-9
Molecular Formula: C27H28Cl4N6
Formula Weight: 578.36
Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial names.
Acriflavine HCl is a compound predominantly used in cellular biology for fluorescence staining. It intercalates between the base pairs of DNA and RNA. Among the acridine dyes, acriflavine has the highest affinity for DNA. Acriflavine stains eukaryotic cells exceptionally well in humic substance environments. It provides a robust experimental consistency and reduces the effect of minor experimental errors. The binding of acriflavine to DNA can be observed from a characteristic red shift in an absorption spectrum. While having a high affinity for DNA, acriflavine is limited to euchromatin for both DNA and RNA.