Bendamustine hydrochloride exerts its anti-cancer affect by a process called alkylation. Alkylation damages the DNA of cells, which prevents them from dividing, and causes them to die. Since cancer cells, in general, divide faster and with less error-correcting than healthy cells, cancer cells are more sensitive to this damage.
Bendamustine side effects
ever, chills, or itching during or shortly after the injection;
pain, swelling, redness, skin changes, or signs of infection where the medicine was injected;
severe ongoing nausea, vomiting, or diarrhea;
liver problems--loss of appetite, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
signs of tumor cell breakdown--confusion, fast or slow heart rate, fluttering in your chest, vomiting, diarrhea, tingling in your hands or feet, tingling around your mouth.
Administer this drug via IV infusion over 10 or 60 minutes; consult the manufacturer product information for specific IV infusion time period.
Treatment of indolent B-Cell non-Hodgkin lymphoma that has progressed during or within 6 months of treatment with rituximab or a rituximab-containing regimen.