What is Dactinomycin injection:
Dactinomycin is a chemotherapy medication given to treat variety of sorts of cancer.
This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm,
carcinoma, and certain sorts of ovarian cancer. It's given by injection into a vein.
Dactinomycin injection Uses:
Dactinomycin is a clear, yellowish liquid administered intravenously and most ordinarily
utilized in treatment of a spread of cancers, including:
1) Gestational trophoblastic neoplasia
2) Wilms' tumor
4) Ewing's sarcoma
5) Malignant hydatid mole
6) Sometimes it'll be combined with other drugs in chemotherapy regimens, just like the VAC regimen
(with vincristine and cyclophosphamide) for treating rhabdomyosarcoma and Ewing's sarcoma.
7) It is also used as a radiosensitizer in adjunct to radiotherapies, since it can increase the radiosensitivity
of tumor cells by inhibiting repair of sublethal radiation damage and delay the onset of the compensatory
hyperplasia that happens following irradiation.
Dactinomycin injection Working, Mechanism of Action and Pharmacology:
In cell biology, Dactinomycin is shown to possess the power to inhibit transcription. Dactinomycin does this by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase. Pharmacodynamics. Generally, the dactinomycins exert an inhibitory effect on gram-positive and gram-negative bacteria and on some fungi. The dactinomycins are cytotoxic, they have an antineoplastic effect. This cytotoxic action is that the basis for their use within the treatment of certain sorts of cancer. Dactinomycin is believed to supply its cytotoxic effects by binding DNA and inhibiting RNA synthesis.
Dactinomycin injection Side-effects:
Common adverse drug reaction includes bone marrow suppression, fatigue, hair loss, mouth ulcer, loss of appetite and diarrhea. Dactinomycin is a vesicant, if extravasation occurs.
Dactinomycin injection- How to Use:
Read the directions on the label, patient guide, or medicine guide by the drugs company or ask your pharmacist before beginning to use. If you've got any questionsassociated with this medicine, ask your doctor or pharmacist. Use this medicine as recommended by your doctor.