Mesna is a medication used in those taking ifosfamide to decrease the risk of bleeding from the bladder.
-Soft tissue sarcoma
-Small cell lung cancer
Incidence of hemorrhagic cystitis
As mucolytic agent
MECHANISM OF ACTION:
It works by disrupting the duplication of DNA and the creation of RNA, thus inhibiting the formation of cancer cells.
Mesna reduces the toxicity of urotoxic compounds that may form after chemotherapy administration, by reduces the urotoxic compounds to unharmful metabolites.
Blood in the urine
PRECAUTION AND HOW TO USE:
The drug should be administered under the supervision of an experienced cancer chemotherapy physician.
Bone marrow suppression may occur.
Confusion and coma due to CNS toxicity have been associated with therapy. Discontinue therapy if it occurs.
Avoid in pregnancy.
Use caution in renal impairment.